An in vitro, in utero and in silico framework of oxygen diffusion in intricate vascular networks of the placenta

• Published in: bioRxiv
• Main Authors: Bappoo, Nikhilesh, Kelsey, Lachlan J, Tongpob, Yutthapong, Feindel, Kirk W, Harrison Caddy, Wyrwoll, Caitlin S, Doyle, Barry J
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 01.12.2021
• Subjects: Adaptation; Blood flow; Computer applications; Fetuses; Magnetic resonance imaging; Oxygenation; Perfusion; Placenta; Structure-function relationships

The placenta is a temporary and complex organ critical for fetal development through its subtle but convoluted harmonization of endocrine, vascular, haemodynamic and exchange adaptations. Yet, due to experimental, technological and ethical constraints, this unique organ remains poorly understood. In...