Optimization of PVA Concentration and Receiver Phase Volume in the Preparation of Rutin Microparticles

Microparticles, which range in size from 1 to 1000 micrometers, are used as multiunit drug delivery systems with well-defined physiological and pharmacokinetic benefits in order to improve efficacy, tolerance, and patient compliance [5]. Results & Discussion This research is an experimental stud...

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Bibliographic Details
Published inJournal of pharmaceutical sciences and research Vol. 13; no. 10; pp. 615 - 616
Main Authors Desnita, Rise, Luliana, Sri
Format Journal Article
LanguageEnglish
Published Cuddalore Journal of Pharmaceutical Sciences and Research 01.10.2021
Subjects
Bioavailability
Drug delivery systems
Efficiency
Ethanol
Nanoparticles
Nonsteroidal anti-inflammatory drugs
Optimization
Solvents
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Summary:Microparticles, which range in size from 1 to 1000 micrometers, are used as multiunit drug delivery systems with well-defined physiological and pharmacokinetic benefits in order to improve efficacy, tolerance, and patient compliance [5]. Results & Discussion This research is an experimental study to provide an overview of optimization in the manufacture of microparticles. Because of its potential benefits such as enhanced bioavailability, reduced risk of systemic toxicity, reduced risk of local irritation, and predictable gastric emptying, microparticulate drug delivery system has recently received a lot of attention in comparison to single unit systems [7]. Ethanol was used as a cosolvent to dissolve rutin. while the addition of dichloromethane will help the solvent evaporation process run faster to produce microparticles. References [1] B. Gullón, T. A. Lú-Chau, M. T. Moreira, J. M. Lema, and G. Eibes, "Rutin: A review on extraction, identification and purification methods, biological activities and approaches to enhance its bioavailability," Trends in Food Science & Technology, vol. 67, pp. 220-235, Sep. 2017, doi: 10.1016/j.tifs.2017.07.008.
ISSN:0975-1459