EphA2 overexpression reduces H2O2-induced damage of lens epithelial cells Cellular, Molecular and Developmental Genetics

• Published in: Genetics and molecular biology Vol. 44; no. 3; p. 1
• Main Authors: Ji, Qingshan, Liu, Jing, Wang, Guifang, Liu, Lian, Zhong, Jingxiang
• Format: Journal Article
• Language: English
• Published: Ribeirao Preto Sociedade Brasileira de Genetica 01.01.2021
• Subjects: Apoptosis; Bcl-2 protein; Caspase-3; Cataracts; Cell viability; Damage; Developmental genetics; EphA2 protein; Epithelial cells; Epithelium; Genetics; Hydrogen peroxide; Lenses; Reactive oxygen species

Age-related cataract (ARC) is a progressive lens opacification that occurs from middle to old age. Eph-receptor tyrosinekinase-type A2 (EphA2) has been reported to be associated with ARC. This work aims to investigate the molecular mechanism of EphA2 in ARC. We treated human lens epithelial cells (S...