A Double Deprotonation Strategy for Cascade Annulations of Palladium–Trimethylenemethanes and Morita–Baylis–Hillman Carbonates to Construct Bicyclohexane Frameworks

• Published in: Angewandte Chemie International Edition Vol. 60; no. 25; pp. 13913 - 13917
• Main Authors: Zhen‐Hong Yang, Chen, Peng, Zhi‐Chao Chen, Chen, Zhi, Du, Wei, Ying‐Chun Chen
• Format: Journal Article
• Language: English
• Published: Weinheim Wiley Subscription Services, Inc 01.06.2021
• Edition: International ed. in English
• Subjects: Activated carbon; Aldehydes; Carbonates; Chemical reactions; Dipoles; Enantiomers; Hexanes; Ketones; Palladium; Substrates

Here we report that the chemoselective activation of Tsuji's 2‐(cyanomethyl)allyl carbonates to generate the palladium–trimethylenemethane 1,3‐dipoles via a deprotonation strategy can be realized in the presence of Morita–Baylis–Hillman carbonates from substantial activated ketones. The followi...