Salvia divinorum increases alcohol intake and tonic immobility whilst decreasing food intake in Wistar rats

• Published in: Acta neurobiologiae experimentalis Vol. 81; no. 1; p. 34
• Main Authors: Vázquez-León, Priscila, Arenas-Martínez, Ulises, Córdova-Maqueda, Dafne, Fregoso-Aguilar, Tomás, Juan, Eduardo Ramírez-San, Miranda-Páez, Abraham
• Format: Journal Article
• Language: English
• Published: Warsaw Polish Academy of Sciences 01.04.2021
• Subjects: Alcohol use; Alcoholic beverages; Alcohols; Animal models; Consummatory behavior; Drug abuse; Exposure; Food; Food intake; Narcotics; Opioid receptors (type kappa); Reinforcement; Rodents; Salvia divinorum; Tonic immobility

The kappa‑opioid system (KOP) is the key in drug abuse. Of all the compounds isolated from Salvia divinorum (S. divinorum), salvinorin‑A (Sal‑A) is predominant. Further, Sal‑A is the only compound within S. divinorum which is reported to have psychoactive properties as a powerful kappa‑opioid recept...