Balancing positive and negative selection: in vivo evolution of Candida lusitaniae MRR1

• Published in: bioRxiv
• Main Authors: Demers, Elora G, Stajich, Jason, Ashare, Alix, Occhipinti, Patricia, Hogan, Deborah A
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 01.12.2020
• Subjects: Alleles; Antimicrobial peptides; Bronchopulmonary infection; Candida; Chronic infection; Drug resistance; Evolution; Fluconazole; Genetic analysis; Genetic suppression; Genomic analysis; Genomics; Host-pathogen interactions; Hydrogen peroxide; Infections; Leukocytes (neutrophilic); MDR1 protein; Mutation; Negative selection; P-Glycoprotein; Pathogens; Population genetics; Reactive oxygen species; Subpopulations; Virulence

Abstract The evolution of pathogens in response to selective pressures present during chronic infections can influence persistence, virulence, and the outcomes of antimicrobial therapy. Because subpopulations within an infection can be spatially separated and the host environment can fluctuate, an a...