MYC overexpression leads to increased chromatin interactions at superenhancers and c-Myc binding sites

• Published in: bioRxiv
• Main Authors: Yi Xiang See, Chen, Kaijing, Fullwood, Melissa J
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 05.01.2021
• Subjects: Acetylation; Binding sites; c-Myc protein; Cancer; Cancer therapies; Chromatin; Enhancers; Histones; Myc protein; Osteosarcoma; Transcription factors

Abstract The MYC oncogene encodes for the c-Myc protein and is frequently dysregulated across multiple cancer cell types, making it an attractive target for cancer therapy. There have been many difficulties in targeting c-Myc, due to its complex network of regulators and the unstructured nature of i...