Multi-Drug-Resistance in Drug-Naive and Drug-Exposed Ovarian Cancer Cells Responds Differently to Cell Culture Dimensionality

• Published in: bioRxiv
• Main Authors: Koshkin, Vasilij, Mariana Bleker De Oliveira, Peng, Chun, Ailles, Laurie E, Liu, Geoffrey, Covens, Allan, Krylov, Sergey N
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 29.07.2020
• Subjects: Cell culture; Cell number; Cytometry; Drug resistance; Multidrug resistance; Ovarian cancer; Spheroids

Does cell clustering in ovarian cancer influence intrinsic and acquired multi-drug resistance (MDR) differently? To address this question, we studied cultured monolayers (representing individual cells) and cultured spheroids (representing clusters) formed by drug-naive (intrinsic MDR) and drug-expos...