Computer-aided whole-cell design: taking a holistic approach by integrating synthetic with systems biology

• Published in: arXiv.org
• Main Authors: Marucci, Lucia, Barberis, Matteo, Karr, Jonathan, Ray, Oliver, Race, Paul R, de Souza Andrade, Miguel, Grierson, Claire, Hoffmann, Stefan Andreas, Landon, Sophie, Rech, Elibio, Rees-Garbutt, Joshua, Seabrook, Richard, Shaw, William, Woods, Christopher
• Format: Paper
• Language: English
• Published: Ithaca Cornell University Library, arXiv.org 04.06.2020
• Subjects: Biology; CAD; Computer aided design; Deoxyribonucleic acid; Design; DNA; Genetic engineering; Modular design; Modularity; Robustness (mathematics); Software; Synthetic biology

Computer-aided design for synthetic biology promises to accelerate the rational and robust engineering of biological systems; it requires both detailed and quantitative mathematical and experimental models of the processes to (re)design, and software and tools for genetic engineering and DNA assembl...