The role of matrix metalloproteinase-9 (MMP-9) in neurodevelopmental deficits and experience-dependent structural plasticity in Xenopus laevis tadpoles

• Published in: bioRxiv
• Main Authors: Gore, Sayali, James, Eric J, Lin-Chien, Huang, Park, Jenn J, Berghella, Andrea, Cline, Hollis T, Aizenman, Carlos D
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 31.05.2020
• Subjects: Developmental plasticity; Endopeptidase; Extracellular matrix; Gelatinase B; Juveniles; Matrix metalloproteinase; Metalloproteinase; Neural networks; Neurodevelopmental disorders; Seizures; Social behavior; Valproic acid; Xenopus

Matrix metalloproteinase-9 is a secreted endopeptidase targeting extracellular matrix proteins, creating permissive environments for neuronal development and plasticity. Developmental dysregulation of MMP-9 may also lead to neurodevelopmental disorders (ND). Here we test the hypothesis that chronica...