Mechanical Low-Pass Filtering of Cells for Detection of Circulating Tumor Cells in Whole Blood10.1021/acs.analchem.9b03939

• Published in: Analytical chemistry (Washington) Vol. 92; no. 3; p. 2483
• Main Authors: Suzuki, Taiki, Kaji, Noritada, Yasaki, Hirotoshi, Yasui, Takao, Baba, Yoshinobu
• Format: Journal Article
• Language: English
• Published: Washington American Chemical Society 04.02.2020
• Subjects: Analytical chemistry; Antibodies; Antigens; Blood; Cell adhesion; Cell adhesion & migration; Cell adhesion molecules; Cell surface; Chemical compounds; Chemistry; Constrictions; Diagnostic systems; Dilution; Epithelial cells; Fluorescence; Fluorophores; Invasiveness; Low pass filters; Lymphocytes; Lymphocytes T; Mechanical analysis; Microfluidic devices; Microfluidics; Pretreatment; Tumor cells; Tumors

The detection of circulating tumor cells (CTCs) from liquid biopsies using microfluidic devices is attracting a considerable amount of attention as a new, less-invasive cancer diagnostic and prognostic method. One of the drawbacks of the existing antibody-based detection systems is the false negativ...