Dietary Ziziphus jujuba Fruit Attenuates Colitis-Associated Tumorigenesis: A Pivotal Role of the NF-[kappa]B/IL-6/JAK1/STAT3 Pathway

• Published in: Nutrition and cancer Vol. 72; no. 1; p. 120
• Main Authors: Periasamy, Srinivasan, Wu, Wang-Hung, Chien, Se-Ping, Liu, Chuan-Teng, Liu, Ming-Yie
• Format: Journal Article
• Language: English
• Published: Mahwah Taylor & Francis Ltd 01.01.2020
• Subjects: Anti-inflammatory agents; Azoxymethane; Cancer; Colon; Colon cancer; Colorectal carcinoma; Dextran; Dextran sulfate; Diarrhea; Diet; Drinking water; Flavonoids; Fruits; Inflammatory bowel disease; Inflammatory bowel diseases; Interleukin 6; Intestine; Janus kinase; NF-κB protein; Polysaccharides; Risk analysis; Risk factors; Saccharides; Signal transduction; Signaling; Sodium; Spleen; Stat3 protein; Tumorigenesis; Tumors; Ulcerative colitis; Variance analysis; Ziziphus jujuba

Inflammatory bowel disease (IBD) including ulcerative colitis (UC) is one of the risk factors for the development of colitis-associated colon cancer (CAC). CAC is a type of colorectal cancer (CRC), the third leading cause of cancer death. Ziziphus jujuba (ZJ) fruit contains bioactive components such...