Roles for p21waf1/cip1 and p27kip1 during the adaptation response to massive intestinal resection

• Published in: American journal of physiology: Gastrointestinal and liver physiology Vol. 53; no. 5; p. G933
• Main Authors: Stehr, Wolfgang, Bernal, Nicole P, Erwin, Christopher R, Bernabe, Kathryn Q
• Format: Journal Article
• Language: English
• Published: Bethesda American Physiological Society 01.05.2006
• Subjects: Adaptation; Apoptosis; Proteins; Rodents; Small intestine

The magnitude of gut adaptation is a decisive factor in determining whether patients are able to live independent of parenteral nutrition after massive small bowel loss. We previously established that the cyclin-dependent kinase inhibitor (CDKI) p21waf1/cip1 is necessary for enterocyte proliferation...