Dietary NaCl supplementation prevents muscle necrosis in a mouse model of Duchenne muscular dystrophy

• Published in: American journal of physiology. Regulatory, integrative and comparative physiology Vol. 59; no. 2; p. R449
• Main Authors: Yoshida, Mizuko, Yonetani, Akira, Shirasaki, Toshihiro, Keiji, W
• Format: Journal Article
• Language: English
• Published: Bethesda American Physiological Society 01.02.2006
• Subjects: Blood; Calcium; Dietary supplements; Muscular dystrophy; Potassium; Rodents; Zinc

The mdx mouse is an animal model for Duchenne muscular dystrophy. Mdx mice fed a 12% NaCl diet from birth up to 20 days of age (mdx-Na mice) had an ~50% reduction in serum creatine kinase (CK) activity compared with mdx mice fed a standard diet. Most notably, necrotic fibers in tibialis anterior (TA...