Phosphorylation of phospholamban at threonine-17 reduces cardiac adrenergic contractile responsiveness in chronic pressure overload-induced hypertrophy

• Published in: American journal of physiology. Heart and circulatory physiology Vol. 291; no. 1; p. 30
• Main Authors: Mills, Geoffrey D, Kubo, Hajime, Harris, David M, Berretta, Remus M
• Format: Journal Article
• Language: English
• Published: Bethesda American Physiological Society 01.07.2006
• Subjects: Cardiology; Heart; Hypotheses; Phosphates; Proteins; Stress

Physiological hemodynamic stress, such as aerobic exercise, is intermittent and requires an increase in Ca^sup 2+^-dependent contractility through sympathetic nervous system activation. Pathological hemodynamic stress, such as hypertension, is persistent and requires sustained increases in cardiac f...