Effect of ppGpp on Escherichia coli cyclopropane fatty acid synthesis is mediated through the RposS sigma factor (sigmaS)

• Published in: Journal of bacteriology Vol. 181; no. 2; p. 572
• Main Authors: Eichel, Johannes, Chang, Ying-Ying, Riesenberg, Dieter, Cronan, John E
• Format: Journal Article
• Language: English
• Published: Washington American Society for Microbiology 01.01.1999
• Subjects: Amino acids; Bacteriology; Genes; Mutation; Proteins

Strains of Escherichia coli carrying mutations at the relA locus are deficient in cyclopropane fatty acid (CFA) synthesis, a phospholipid modification that occurs as cultures enter stationary phase. RelA protein catalyzes the synthesis of guanosine-3',5'-bisdiphosphate (ppGpp); therefore,...