The PTPN22 1858T Gene Variant in Type 1 Diabetes Is Associated With Reduced Residual [beta]-Cell Function and Worse Metabolic Control

• Published in: Diabetes care Vol. 31; no. 6; p. 1214
• Main Authors: Petrone, Antonio, Spoletini, Marialuisa, Zampetti, Simona, Capizzi, Marco, Zavarella, Sara, Osborn, John, Pozzilli, Paolo, Buzzetti, Raffaella
• Format: Journal Article
• Language: English
• Published: Alexandria American Diabetes Association 01.06.2008
• Subjects: Autoimmune diseases; Cells; Clinical trials; Diabetes; Disease; Genomics; Genotype & phenotype; Immunotherapy

Evidence has been reported for a new susceptible locus for type 1 diabetes, the protein tyrosine phosphatase nonreceptor type 2 (PTPN22), which encodes a lymphoid-specific phosphatase. The aim of the study was to evaluate the influence of the C1858T variant of the PTPN22 gene on β-cell function as m...