Sustained exposure to bacterial antigen induces interferon-[gamma]-dependent T cell receptor [zeta] down-regulation and impaired T cell function

• Published in: Nature immunology Vol. 4; no. 10; p. 957
• Main Authors: Bronstein-Sitton, Noemí, Cohen-Daniel, Leonor, Vaknin, Ilan, Ezernitchi, Analía V, Leshem, Benny, Halabi, Amal, Houri-Hadad, Yael, Greenbaum, Eugenia, Zakay-Rones, Zichria, Shapira, Lior, Baniyash, Michal
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group 01.10.2003
• Subjects: Exposure; Immune response; Infectious diseases; Physiology

T cell antigen receptor zeta chain down-regulation and impaired in vitro T cell function have been described in cancer and autoimmune and infectious diseases. However, the immunological basis for this phenomenon is unknown. Sustained exposure to antigen and chronic systemic inflammation, factors sha...