An interaction between ATP and high K^sup +^: Mutual impairment of ATP- and high K^sup +^-evoked [Ca^sup 2+^]^sub i^ increase in NG 108-15 cells
The interaction between ATP- and high K(+)-evoked increase in intracellular free calcium concentration ([Ca2+]i) was investigated to gain an insight into the mechanism of interaction of ATP with voltage-sensitive calcium channels. [Ca2+]i was measured in the neuronal model, neuroblastoma x glioma hy...
Saved in:
Published in | Neurochemical research Vol. 27; no. 6; p. 451 |
---|---|
Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
New York
Springer Nature B.V
01.06.2002
|
Online Access | Get full text |
Cover
Loading…
Abstract | The interaction between ATP- and high K(+)-evoked increase in intracellular free calcium concentration ([Ca2+]i) was investigated to gain an insight into the mechanism of interaction of ATP with voltage-sensitive calcium channels. [Ca2+]i was measured in the neuronal model, neuroblastoma x glioma hybrid cells (NG 108-15), using the fluorescence indicator fura-2. In the presence of 1.8 mM extracellular Ca2+, ATP induced a rapid, concentration-dependent increase in [Ca2+]i. High K+ (50 mM) evoked a [Ca2+]i rise from 109 +/- 11 nM to 387 +/- 81 nM (n = 16). The application of either of these two [Ca2+]i-increase provoking agents in sequence with the other caused impairment of the latter effect. The mutual desensitization of the responses to ATP and high K+ strongly suggests that both agents rely at least in part on the same source of Ca2+ for elevation of [Ca2+]i in NG 108-15 cells. |
---|---|
AbstractList | The interaction between ATP- and high K(+)-evoked increase in intracellular free calcium concentration ([Ca2+]i) was investigated to gain an insight into the mechanism of interaction of ATP with voltage-sensitive calcium channels. [Ca2+]i was measured in the neuronal model, neuroblastoma x glioma hybrid cells (NG 108-15), using the fluorescence indicator fura-2. In the presence of 1.8 mM extracellular Ca2+, ATP induced a rapid, concentration-dependent increase in [Ca2+]i. High K+ (50 mM) evoked a [Ca2+]i rise from 109 +/- 11 nM to 387 +/- 81 nM (n = 16). The application of either of these two [Ca2+]i-increase provoking agents in sequence with the other caused impairment of the latter effect. The mutual desensitization of the responses to ATP and high K+ strongly suggests that both agents rely at least in part on the same source of Ca2+ for elevation of [Ca2+]i in NG 108-15 cells. |
Author | Sheng-Nan, Li Hu, Gang Brater, Manfred Klaus, Andreas Ravens, Ursula |
Author_xml | – sequence: 1 givenname: Li surname: Sheng-Nan fullname: Sheng-Nan, Li – sequence: 2 givenname: Gang surname: Hu fullname: Hu, Gang – sequence: 3 givenname: Manfred surname: Brater fullname: Brater, Manfred – sequence: 4 givenname: Andreas surname: Klaus fullname: Klaus, Andreas – sequence: 5 givenname: Ursula surname: Ravens fullname: Ravens, Ursula |
BookMark | eNqNjc1KQzEUhINU8Lb6Dge3JXCS2Nq6K8UfEMVFd8Vb0ttTm3p7cs2PvoaPbBR3blwMM8x8MH3RY890JCo1ujRyPEXTExWa8YU0aoonoh_jHlEhalWJzxmD40TBNsl5hjWlDyKG2eIJLG9g5152cF_H3MGwvoKHnLJtwR0668KBOIHffrPyLyzp3b_SBpZz-9PoYf1cwhpcXR6bQDZSCfB4CwonUo2gobaNp-J4a9tIZ78-EOc314v5neyCf8sU02rvc-AyrbRWEzS66F_QF47uVDg |
ContentType | Journal Article |
Copyright | Copyright Kluwer Academic Publishers Jun 2002 |
Copyright_xml | – notice: Copyright Kluwer Academic Publishers Jun 2002 |
DBID | 3V. 7QR 7TK 7U7 7X7 7XB 88A 88E 8AO 8FD 8FE 8FH 8FI 8FJ 8FK ABUWG AFKRA AZQEC BBNVY BENPR BHPHI C1K CCPQU DWQXO FR3 FYUFA GHDGH GNUQQ HCIFZ K9. LK8 M0S M1P M7P P64 PQEST PQQKQ PQUKI PRINS |
DatabaseName | ProQuest Central (Corporate) Chemoreception Abstracts Neurosciences Abstracts Toxicology Abstracts ProQuest_Health & Medical Collection ProQuest Central (purchase pre-March 2016) Biology Database (Alumni Edition) Medical Database (Alumni Edition) ProQuest Pharma Collection Technology Research Database ProQuest SciTech Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central ProQuest Central Essentials Biological Science Collection ProQuest Central ProQuest Natural Science Collection Environmental Sciences and Pollution Management ProQuest One Community College ProQuest Central Korea Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student SciTech Premium Collection (Proquest) (PQ_SDU_P3) ProQuest Health & Medical Complete (Alumni) Biological Sciences Health & Medical Collection (Alumni Edition) PML(ProQuest Medical Library) Biological Science Database Biotechnology and BioEngineering Abstracts ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China |
DatabaseTitle | ProQuest Central Student Technology Research Database ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central China Environmental Sciences and Pollution Management ProQuest Biology Journals (Alumni Edition) ProQuest Central Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Natural Science Collection ProQuest Central Korea Biological Science Collection Chemoreception Abstracts ProQuest Medical Library (Alumni) ProQuest Biological Science Collection Toxicology Abstracts ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database ProQuest SciTech Collection Neurosciences Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition Engineering Research Database ProQuest One Academic ProQuest Central (Alumni) |
DatabaseTitleList | ProQuest Central Student |
Database_xml | – sequence: 1 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Anatomy & Physiology |
EISSN | 1573-6903 |
ExternalDocumentID | 404175391 |
GroupedDBID | --- -4W -56 -5G -BR -EM -Y2 -~C -~X .86 .GJ .VR 06C 06D 0R~ 0VY 123 199 1N0 1SB 203 29N 29~ 2J2 2JN 2JY 2KG 2KM 2LR 2P1 2VQ 2~H 30V 3V. 4.4 406 408 409 40D 40E 53G 5VS 67N 67Z 6NX 78A 7QR 7TK 7U7 7X7 7XB 88A 88E 8AO 8FD 8FE 8FH 8FI 8FJ 8FK 8TC 8UJ 95- 95. 95~ 96X AAAVM AABHQ AACDK AAHNG AAIAL AAJBT AAJKR AANXM AANZL AARHV AARTL AASML AATNV AATVU AAUYE AAWCG AAYIU AAYQN AAYTO ABAKF ABBBX ABBXA ABDZT ABECU ABFTV ABHLI ABHQN ABJNI ABJOX ABKCH ABKTR ABMNI ABMQK ABNWP ABPLI ABQBU ABSXP ABTEG ABTHY ABTKH ABTMW ABULA ABUWG ABWNU ABXPI ACAOD ACBXY ACDTI ACGFS ACHSB ACHXU ACIPQ ACIWK ACKNC ACMDZ ACMLO ACOKC ACOMO ACPRK ACZOJ ADBBV ADHHG ADHIR ADIMF ADINQ ADKNI ADKPE ADRFC ADTPH ADURQ ADYFF ADZKW AEBTG AEFQL AEGAL AEGNC AEJHL AEJRE AEKMD AEMSY AENEX AEOHA AEPYU AESKC AETLH AEVLU AEXYK AFBBN AFFNX AFGCZ AFKRA AFLOW AFQWF AFRAH AFWTZ AFZKB AGAYW AGDGC AGJBK AGMZJ AGQEE AGQMX AGRTI AGWIL AGWZB AGYKE AHBYD AHKAY AHMBA AHSBF AHYZX AIAKS AIGIU AILAN AITGF AJBLW AJRNO AJZVZ AKMHD ALIPV ALMA_UNASSIGNED_HOLDINGS ALWAN AMKLP AMXSW AMYLF AMYQR AOCGG ARMRJ ASPBG AVWKF AXYYD AZFZN AZQEC B-. BA0 BBNVY BDATZ BENPR BGNMA BHPHI BPHCQ BVXVI C1K CAG CCPQU COF CS3 CSCUP DDRTE DL5 DNIVK DPUIP DU5 DWQXO EBLON EBS EIOEI EJD EN4 EPAXT ESBYG F5P FEDTE FERAY FFXSO FIGPU FINBP FNLPD FR3 FRRFC FSGXE FWDCC FYUFA G-Y G-Z GGCAI GGRSB GJIRD GNUQQ GNWQR GQ6 GQ7 GQ8 GXS H13 HCIFZ HF~ HG5 HG6 HMCUK HMJXF HQYDN HRMNR HVGLF HZ~ I09 IHE IJ- IKXTQ ITM IWAJR IXC IZIGR IZQ I~X I~Z J-C J0Z JBSCW JCJTX JZLTJ K9. KDC KOV KPH LAK LK8 LLZTM M0L M1P M4Y M7P MA- N2Q N9A NB0 NPVJJ NQJWS NU0 O9- O93 O9G O9I O9J OAM OVD P19 P2P P64 PF0 PQEST PQQKQ PQUKI PRINS PROAC PSQYO PT4 PT5 Q2X QOK QOR QOS R89 R9I RHV RNI RNS ROL RPX RRX RSV RZC RZE S16 S27 S3A S3B SAP SBL SDH SDM SHX SISQX SJYHP SNE SNPRN SNX SOHCF SOJ SPISZ SRMVM SSLCW SSXJD STPWE SZN T13 TEORI TSG TSK TSV TUC U2A U9L UG4 UKHRP UOJIU UTJUX UZXMN VC2 VFIZW W23 W48 WJK WK8 XJT YLTOR Z45 Z7U Z82 Z83 Z87 Z8O Z8V Z91 ZGI ZMTXR ZOVNA ~EX |
ID | FETCH-proquest_journals_2218032803 |
IEDL.DBID | BENPR |
ISSN | 0364-3190 |
IngestDate | Thu Oct 10 22:05:43 EDT 2024 |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 6 |
Language | English |
LinkModel | DirectLink |
MergedId | FETCHMERGED-proquest_journals_2218032803 |
PQID | 221803280 |
PQPubID | 37979 |
ParticipantIDs | proquest_journals_221803280 |
PublicationCentury | 2000 |
PublicationDate | 20020601 |
PublicationDateYYYYMMDD | 2002-06-01 |
PublicationDate_xml | – month: 06 year: 2002 text: 20020601 day: 01 |
PublicationDecade | 2000 |
PublicationPlace | New York |
PublicationPlace_xml | – name: New York |
PublicationTitle | Neurochemical research |
PublicationYear | 2002 |
Publisher | Springer Nature B.V |
Publisher_xml | – name: Springer Nature B.V |
SSID | ssj0010021 |
Score | 3.3508425 |
Snippet | The interaction between ATP- and high K(+)-evoked increase in intracellular free calcium concentration ([Ca2+]i) was investigated to gain an insight into the... |
SourceID | proquest |
SourceType | Aggregation Database |
StartPage | 451 |
Title | An interaction between ATP and high K^sup +^: Mutual impairment of ATP- and high K^sup +^-evoked [Ca^sup 2+^]^sub i^ increase in NG 108-15 cells |
URI | https://www.proquest.com/docview/221803280 |
Volume | 27 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3fSwJBEB5SX3qJyqKyZIjoRZbOc891e4lTNCk8JAyE6MTzVpDozjwN-i_6k9tZV18CX47lbrljb-_mmx_fzADcRFUxkVIoxlXkMI23kknpTZl060JJDVGuYVX2gnr3lT8NvaHl5mSWVrmRiUZQx-mEfOR3rsYiqv3mPMy_GDWNouCq7aCRg4Jb5RSlLTTbQf9lG0YgBFsHK7kWNtL5J3ANinQO4cCqf-iv9-sI9lRyDEU_0abv5w_eoiFkGk93EX79BKmaw2Kde4CWUoX-oI_a_keqNIzPYbaaYyW8x96KUkGQ0h5nC_L5YTqluez_ZKa-0w8V41trbM64lfBdDyKchfqJpEdmSg8weMQq1WX1kPz72Qlcd9qDVpdtVjeyX2I22r632inkkzRRZ4Aej7XVpyLRqGuFRP_CDcHjmjOO9HEcN_g5lHbc6GLn1RLsm4YpxlFxCfnlYqWuNG4vozLkxFCUoeB3ms2gbPfqD-AWnyg |
link.rule.ids | 315,786,790,12083,21416,31752,33777,43343,43838,74100,74657 |
linkProvider | ProQuest |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1LS8NAEB60HvQiahVrfQwiXspimmyarhcJxVrtAw8VCmJK02yhiEltWsF_4U92Zpv2UuglLMmSsI_Ma7_5BuAmLHtDpTwtpA4tQfpWCaXckVB2xdOKVJRtUJXtTqXxJl96bi_D5qQZrHIpE42gjpIhx8jvbNJFzP1mPUy-BReN4sPVrILGNuxIx5G8zb3eyt9ictHy4qhSkqhR1pq4NTqkfgD7mfGH_mK1DmFLx0eQ92NyfL9-8RYNHNPEufPw58fIXA7TReYBZoAq9LuvSN4_Ms8wNoN0PsFScI_tOSeCICc9jqcc8cNkxH3Femehf5JPHeF7bWDu2KXggxohjgP6IluRqaYGdp6wzKysLnJ0Pz2G6_pjt9YQy9H1s32Y9lez5pxALk5ifQroyoh8Ph161QqZI_QDVz0ZOdYgpOsgqsoCFDe86Gzj0yvYbXTbrX7rudMswp4pnWJCFueQm03n-oI0-Cy8NOv0Dw-Ynkw |
linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3fS8NADA46QXwRdYo6fwQRX8axrmvXnS9SpnM6N_YwYSB2tOsNhtjOdRP8L_yTTW43XwZ7KUd7tFzT5ktyyReA66jsDaX0lHBUZAnCWymkdEdC2lVPSYIoW2dVtjvV5qvz3Hf7hlIoM2mVS52oFXWcDjlGXrIJi5j7zSqNTFZE975xN_kS3ECKN1pNN41N2CKQtLiLg9f_972YaLS82LZ0SO1Ia0X1ajxp7MGuMQTRX0huHzZUcgB5PyEn-PMHb1CnZuqYdx5-_QSZ12G6qEJAk1yFfq-LYRIjcw5jK8jmEywGt9iec1EIcgHkeMrRP0xHPFesThbqO_1QMb7VQ33GLgbvNIhwHNAT2aLMFA2w84hlZmh1kSP92SFcNR569aZYrm5gvsls8P8GK0eQS9JEHQO6Tkz-n4q8WpVME_qZa54TV6wwomMY15wTKKy50enaq5ewTSIavDx1WgXY0V1UdPTiDHKz6VydE5jPogstpj_bM6J4 |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=An+interaction+between+ATP+and+high+K%5Esup+%2B%5E%3A+Mutual+impairment+of+ATP-+and+high+K%5Esup+%2B%5E-evoked+%5BCa%5Esup+2%2B%5E%5D%5Esub+i%5E+increase+in+NG+108-15+cells&rft.jtitle=Neurochemical+research&rft.au=Sheng-Nan%2C+Li&rft.au=Hu%2C+Gang&rft.au=Brater%2C+Manfred&rft.au=Klaus%2C+Andreas&rft.date=2002-06-01&rft.pub=Springer+Nature+B.V&rft.issn=0364-3190&rft.eissn=1573-6903&rft.volume=27&rft.issue=6&rft.spage=451&rft.externalDBID=HAS_PDF_LINK&rft.externalDocID=404175391 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0364-3190&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0364-3190&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0364-3190&client=summon |