Tricuspid Valve Thrombus and Pulmonary Embolus in an Infant with Homozygous Thermolabile Methylenetetrahydrofolate Reductase and HeterozygousProthrombin G20210A Variant
We describe an unusual and interesting case of a full-term infant presenting at 7 days of life with HSV pneumonitis and a tricuspid valve thrombus ultimately requiring extracorporeal membrane oxygenation. The infant subsequently developed a pulmonary embolus. The infant was found to be heterozygous...
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| Published in | Journal of perinatology Vol. 23; no. 6; p. 513 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
New York
Nature Publishing Group
01.09.2003
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| Online Access | Get full text |
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| Abstract | We describe an unusual and interesting case of a full-term infant presenting at 7 days of life with HSV pneumonitis and a tricuspid valve thrombus ultimately requiring extracorporeal membrane oxygenation. The infant subsequently developed a pulmonary embolus. The infant was found to be heterozygous for the prothrombin G20210A mutation and homozygous for the methylenetetrahydrofolate reductase C667T mutation. The patient was treated with low molecular weight heparin for a total of 3 months and has not had a recurrent thrombosis. This case illustrates that a combination of congenital and acquired thrombophilic risk factors can contribute to a significant thrombotic event. |
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| AbstractList | We describe an unusual and interesting case of a full-term infant presenting at 7 days of life with HSV pneumonitis and a tricuspid valve thrombus ultimately requiring extracorporeal membrane oxygenation. The infant subsequently developed a pulmonary embolus. The infant was found to be heterozygous for the prothrombin G20210A mutation and homozygous for the methylenetetrahydrofolate reductase C667T mutation. The patient was treated with low molecular weight heparin for a total of 3 months and has not had a recurrent thrombosis. This case illustrates that a combination of congenital and acquired thrombophilic risk factors can contribute to a significant thrombotic event. |
| Author | Lattimore, Keri A Pipe, Steven W Thornburg, Courtney D |
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| Copyright | Copyright Nature Publishing Group Sep 2003 |
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| DOI | 10.1038/sj.jp.7210951 |
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| Snippet | We describe an unusual and interesting case of a full-term infant presenting at 7 days of life with HSV pneumonitis and a tricuspid valve thrombus ultimately... |
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| Title | Tricuspid Valve Thrombus and Pulmonary Embolus in an Infant with Homozygous Thermolabile Methylenetetrahydrofolate Reductase and HeterozygousProthrombin G20210A Variant |
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