Apc modulates embryonic stem-cell differentiation by controlling the dosage of [beta]-catenin signaling

• Published in: Nature genetics Vol. 32; no. 4; p. 594
• Main Authors: Kielman, Menno F, Rindapää, Maaret, Gaspar, Claudia, Nicole van Poppel, Breukel, Cor, Sandra van Leeuwen, Taketo, Makoto Mark, Roberts, Scott, Smits, Ron, Fodde, Riccardo
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group 01.12.2002
• Subjects: Cell differentiation; Kinases; Mutation; Proteins; Stem cells; Tissues; Translocation; Tumorigenesis

The Wnt signal-transduction pathway induces the nuclear translocation of membrane-bound beta-catenin (Catnb) and has a key role in cell-fate determination. Tight somatic regulation of this signal is essential, as uncontrolled nuclear accumulation of beta-catenin can cause developmental defects and t...