A subset of lung cancer cases shows robust signs of homologous recombination deficiency associated genomic aberration based molecular signatures

• Published in: bioRxiv
• Main Authors: Diossy, Miklos, Sztupinszki, Zsofia, Borcsok, Judit, Krzystanek, Marcin, Tisza, Viktoria, Spisak, Sandor, Rusz, Orsolya, Timar, Jozsef, Csabai, Istvan, Moldvay, Judit, Anders Gorm Pedersen, Szuts, David, Szallasi, Zoltan
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 28.11.2019
• Subjects: Biopsy; Breast cancer; Clinical trials; DNA repair; Genomes; Homologous recombination; Lung cancer; Next-generation sequencing; Poly(ADP-ribose) polymerase; Prostate cancer; Solid tumors

Background: Consistent with their assumed mechanism of action, PARP inhibitors show significant therapeutic efficacy in breast, ovarian and prostate cancer, which are the solid tumor types most often associated with the loss of function of key homologous recombination genes. It remains unknown, howe...