In vitro activity of AVE1330A, an innovative broad-spectrum non-²-lactam ²-lactamase inhibitor

• Published in: Journal of antimicrobial chemotherapy Vol. 54; no. 2; p. 410
• Main Authors: Bonnefoy, Alain, Dupuis-Hamelin, Claudine, Steier, Valérie, Delachaume, Carole, Seys, Catherine, Stachyra, Thérèse, Fairley, Monique, Guitton, Michèle, Lampilas, Maxime
• Format: Journal Article
• Language: English
• Published: Oxford Oxford Publishing Limited (England) 01.08.2004

Objectives: Production of ²-lactamases is the main mechanism of ²-lactam resistance in Gram-negative bacteria. Despite the current use of clavulanic acid, sulbactam and tazobactam, the prevalence of class A and class C enzymes is increasing worldwide, demanding new ²-lactamase inhibitors. Here we re...