Non-viral VEGF^sub 165^ gene therapy - magnetofection of acoustically active magnetic lipospheres ('magnetobubbles') increases tissue survival in an oversized skin flap model

• Published in: Journal of cellular and molecular medicine Vol. 14; no. 3; p. 587
• Main Authors: Holzbach, Thomas, Vlaskou, Dialekti, Neshkova, Iva, Konerding, Moritz A, Wörtler, Klaus, Mykhaylyk, Olga, Gänsbacher, Bernd, Machens, H-G, Plank, Christian, Giunta, Riccardo E
• Format: Journal Article
• Language: English
• Published: Bucharest Blackwell Publishing Ltd 01.03.2010
• Subjects: Cells; Deoxyribonucleic acid; DNA; Gene therapy; Nanoparticles; Proteins; Signal transduction; Tissues

Adenoviral transduction of the VEGF gene in an oversized skin flap increases flap survival and perfusion. In this study, we investigated the potential of magnetofection of magnetic lipospheres containing VEGF(165)-cDNA on survival and perfusion of ischemic skin flaps and evaluated the method with re...