Muscle-Derived Angiopoietin-Like Protein 4 Is Induced by Fatty Acids via Peroxisome Proliferator-Activated Receptor (PPAR)-[delta] and Is of Metabolic Relevance in Humans

• Published in: Diabetes (New York, N.Y.) Vol. 58; no. 3; p. 579
• Main Authors: Staiger, Harald, Haas, Carina, Machann, Jürgen, Werner, Roman, Weisser, Melanie, Schick, Fritz, Machicao, Fausto, Stefan, Norbert, Fritsche, Andreas, Häring, Hans-Ulrich
• Format: Journal Article
• Language: English
• Published: New York American Diabetes Association 01.03.2009
• Subjects: Body fat; Coronary vessels; Diabetes; Fatty acids; Genes; Genomes; Glucose; Insulin resistance; Lipids; Magnetic resonance imaging; Metabolic syndrome; Musculoskeletal system; Peptides; Plasma; Proteins; Research design; Spectrum analysis

Long-chain fatty acids (LCFAs) contribute to metabolic homeostasis in part via gene regulation. This study's objective was to identify novel LCFA target genes in human skeletal muscle cells (myotubes). In vitro methods included culture and treatment of human myotubes and C2C12 cells, gene array...