Remodeling of Retinal Fatty Acids in an Animal Model of Diabetes: A Decrease in Long-Chain Polyunsaturated Fatty Acids Is Associated With a Decrease in Fatty Acid Elongases Elov12 and Elov14

• Published in: Diabetes (New York, N.Y.) Vol. 59; no. 1; p. 219
• Main Authors: Tikhonenko, Maria, Lydic, Todd A, Wang, Yun, Chen, Weiqin, Opreanu, Madalina, Sochacki, Andrew, McSorley, Kelly M, Renis, Rebecca L, Kern, Timothy, Jump, Donald B, Reid, Gavin E, Busik, Julia V
• Format: Journal Article
• Language: English
• Published: New York American Diabetes Association 01.01.2010
• Subjects: Animals; Chromatography; Cohort analysis; Cytokines; Diabetes; Diabetic retinopathy; Epidemiology; Fatty acids; Gene expression; Glucose; Lipids; Liver; Metabolic disorders; Photoreceptors; Research design; Retina; Tumor necrosis factor-TNF; Vascular endothelial growth factor

The results of the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications cohort study revealed a strong association between dyslipidemia and the development of diabetic retinopathy. However, there are no experimental data on retinal fatty acid metabolism i...