IL-1[beta] induced protein changes in diabetes prone BB rat islets of Langerhans identified by proteome analysis

• Published in: Diabetologia Vol. 45; no. 11; p. 1550
• Main Authors: Sparre, T, Christensen, U Bjerre, P. Mose Larsen, Fey, S, Wrzesinski, K, Roepstorff, P, Mandrup-Poulsen, T, Pociot, F, Karlsen, A, Nerup, J
• Format: Journal Article
• Language: English
• Published: Heidelberg Springer Nature B.V 01.11.2002

Abstract Aims/hypothesis. Type I (insulin-dependent) diabetes mellitus is characterized by selective destruction of the insulin producing beta cells. Interleukin-1β (IL-1β) modulates the beta-cell function, protein synthesis, energy production and causes apoptosis. We have previously shown changes i...