High-fat diet-induced obesity and insulin resistance in CYP4a14^sup −/−^ mice is mediated by 20-HETE

• Published in: American journal of physiology. Regulatory, integrative and comparative physiology Vol. 315; no. 5; p. R934
• Main Authors: Gilani, Ankit, Pandey, Varunkumar, Garcia, Victor, Agostinucci, Kevin, Singh, Shailendra P, Schragenheim, Joseph, Bellner, Lars, Falck, John R, Paudyal, Mahesh P, Capdevila, Jorge H, Abraham, Nader G, Schwartzman, Michal Laniado
• Format: Journal Article
• Language: English
• Published: Bethesda American Physiological Society 01.11.2018
• Subjects: Adipose tissue; Body mass; Body mass index; Body size; Body weight gain; Diet; Glucose; Glucose tolerance; High fat diet; Homeostasis; Hyperglycemia; Hyperinsulinemia; Insulin; Insulin receptor substrate 1; Insulin resistance; Mice; Obesity; Phosphorylation; Rodents; Serine; Signaling; Substrates; Tyrosine

20-Hydroxyeicosatetraenoic acid (20-HETE) has been shown to positively correlate with body mass index, hyperglycemia, and plasma insulin levels. This study seeks to identify a causal relationship between 20-HETE and obesity-driven insulin resistance. Cyp4a14−/− male mice, a model of 20-HETE overprod...