PARP1 as a molecular target for the delivery of theranostic Auger emitters to cancer chromatin

• Published in: The Journal of nuclear medicine (1978) Vol. 59; p. 59
• Main Authors: MaKvandi, Mehran, Winters, Harrison, Weng, Chi-Chang, Puentes, Laura, Hsieh, Chia-Ju, Mankoff, David, Pryma, Daniel, Mach, Robert
• Format: Journal Article
• Language: English
• Published: New York Society of Nuclear Medicine 01.05.2018
• Subjects: Adenosine diphosphate; Auger spectroscopy; Augers; Autoradiography; Cancer; Catalysis; Chromatin; Clonal deletion; CRISPR; Damage; Deoxyribonucleic acid; DNA; DNA damage; DNA repair; Drug delivery systems; Emitters; Emitters (electron); Enzymatic activity; Feasibility; Feasibility studies; Histology; Histones; In vivo methods and tests; Inhibition; Iodine; Iodine 125; Iodine isotopes; Iodine radioisotopes; Medical imaging; Microscopy; Muscles; Nuclear medicine; Ovarian cancer; Photon emission; Poly(ADP-ribose); Poly(ADP-ribose) polymerase; Precision medicine; Proteins; Radioactive tracers; Radioisotopes; Radiology; Restoration; Ribose; Sensitivity; Single photon emission computed tomography; Targeted cancer therapy; Tomography; Tumor cell lines; Tumors

Objectives: Auger emitting radionuclides possess favorable therapeutic properties when targeted to sub-cellular regions that are in close proximity to DNA. Poly(ADP-ribose) Polymerase (PARP) 1 is the second highest expressed nuclear protein after histones and has DNA and chromatin binding properties...