High toxicity of Bi(OH)^sub 3^ and α-Bi^sub 2^O^sub 3^ nanoparticles towards malignant 9L and MCF-7 cells

• Published in: Materials Science & Engineering. C, Biomimetic Materials, Sensors and Systems Vol. 93; p. 958
• Main Authors: Bogusz, K, Tehei, M, Cardillo, D, Lerch, M, Rosenfeld, A, Dou, SX, Liu, HK, Konstantinov, K
• Format: Journal Article
• Language: English
• Published: Lausanne Elsevier BV 01.12.2018
• Subjects: Apoptosis; Bismuth oxides; Bismuth trioxide; Breast cancer; Cancer therapies; Cell death; Confocal microscopy; Flow cytometry; Incubation; Kidneys; Materials science; Microscopy; Morphology; Mortality; Nanomaterials; Nanoparticles; Nanotechnology; Reactive oxygen species; Toxicity

Here we report the extreme toxicity in vitro of Bi(OH)3 and α-Bi2O3 nanoparticles (NPs), obtained through a facile synthesis with an average single particle size of 6–10 nm, tested on malignant gliosarcoma 9L and MCF-7 human breast cancer cells. For both nanomaterials, clonogenic assays reveal a mor...