Interleukin-3 in Cooperation with Transforming Growth Factor [beta] Induces Granulocyte Macrophage Colony Stimulating Factor Independent Differentiation of Human CD34+ Hematopoietic Progenitor Cells into Dendritic Cells with Features of Langerhans Cells

• Published in: Journal of investigative dermatology Vol. 121; no. 6; p. 1397
• Main Authors: Mollah, Zia U A, Aiba, Setsuya, Nakagawa, Satoshi, Mizuashi, Masato, Ohtani, Tomoyuki, Yoshino, Yumiko, Tagami, Hachiro
• Format: Journal Article
• Language: English
• Published: London Elsevier Limited 01.12.2003

Recently, we have reported that M-CSF in cooperation with TGF-beta1 can induce Langerhans cell (LC) development from hematopoietic progenitor cells (HPCs) without GM-CSF. In the present study, we examined whether TGF-beta1 changes the differentiation of HPCs induced by IL-3 towards LC development. W...