Quasispecies and recombination

Recombination is introduced into Eigen's theory of quasispecies evolution. Comparing numerical simulations of the rate equations in the non-recombining and recombining cases show that recombination has a strong effect on the error threshold and, for a wide range of mutation rates, gives rise to...

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Bibliographic Details
Published inarXiv.org
Main Authors Martin Nilsson Jacobi, Nordahl, Mats
Format Paper
LanguageEnglish
Published Ithaca Cornell University Library, arXiv.org 30.11.2005
Subjects
Computer simulation
Crossovers
Dynamic stability
Fitness
Mutation
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Summary:Recombination is introduced into Eigen's theory of quasispecies evolution. Comparing numerical simulations of the rate equations in the non-recombining and recombining cases show that recombination has a strong effect on the error threshold and, for a wide range of mutation rates, gives rise to two stable fixed points in the dynamics. This bi-stability results in the existence of two error thresholds. We prove that, under some assumptions on the fitness landscape but for general crossover probability, a fixed point localized about the sequence with superior fitness is globally stable for low mutation rates.
ISSN:2331-8422