CD161 mediates prenatal immune suppression of IFN -producing PLZF+ T cells

• Published in: bioRxiv
• Main Authors: Halkias, Joanna, Elze Rackaityte, Dvir Aran, Mendoza, Ventura F, Eckalbar, Walter L, Burt, Trevor D
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 21.04.2018
• Subjects: Adaptive immunity; Birth; Cell activation; Cytokines; Fetuses; Health risk assessment; Immune system; Immunological tolerance; Inflammation; Interferon; Intestine; Lymphocytes; Lymphocytes T; Neonates; Pregnancy; Premature birth; Transcription

While the fetal immune system defaults to a program of tolerance, there is concurrent need for protective immunity to meet the antigenic challenges after birth. Activation of fetal T cells is associated with fetal inflammation and the termination of pregnancy, yet which fetal T cells contribute to t...