Unique composition and hyperstability of the ventral disc, Giardias complex microtubule organelle

• Published in: bioRxiv
• Main Authors: Nosala, Christopher, Hagen, Kari D, Jones, Kelci, Loudermilk, Rita, Nguyen, Kristofer, Dawson, Scott C
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 09.10.2018
• Subjects: Ankyrins; Basal bodies; Cytoplasm; Diarrhea; Epithelium; Flagella; Gastrointestinal tract; Genetic analysis; Homology; Peristalsis; Potassium chloride; Protein arrays; Proteins; Small intestine; Trophozoites

Giardia is a common protistan parasite that causes diarrheal disease worldwide. Motile trophozoites colonize the small intestine, attaching to the villi with the ventral disc, a unique and complex microtubule (MT) organelle. Attachment to the host epithelium allows Giardia to resist peristalsis duri...