Extended scrapie incubation time in goats singly heterozygous for PRNP S146 or K222: An update after seven years

• Published in: Journal of animal science Vol. 94; pp. 173 - 174
• Main Authors: White, S, Schneider, D A, Reynolds, J O, O'Rourke, K I, Waldron, D F
• Format: Journal Article
• Language: English
• Published: Champaign Oxford University Press 01.09.2016
• Subjects: Amino acid substitution; Amino acids; Animal husbandry; Biopsy; Caprinae; Genotypes; Goats; Heterozygotes; Homozygotes; Incubation; Inoculation; Prion protein; Prions; Proteins; Scrapie; Sheep; Spongiform encephalopathies; Transmissible spongiform encephalopathy

Scrapie is the transmissible spongiform encephalopathy of sheep and goats, and efforts to eradicate scrapie are underway in many countries worldwide. Goats may serve as a reservoir for scrapie and. to date, there has been no experimental inoculation confirming strong, lifelong genetic resistance in...