Chicken IL-26 regulates immune responses through the JAK/STAT and NF-kB signaling pathways

• Published in: Developmental and comparative immunology Vol. 73; p. 10
• Main Authors: Truong, Anh Duc, Hong, Yeojin, Hoang, Cong Thanh, Lee, Janggeun, Hong, Yeong Ho
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Science Ltd 01.08.2017
• Subjects: Biotechnology; Carbon tetrachloride; CCL4 protein; Cell activation; Cell lines; Cell proliferation; Chemokines; Cytokines; Gene expression; Helper cells; Immune response; Immune system; Induced polarization; Inflammation; Interleukin 10; Interleukin 12; Interleukin 4; Janus kinase 2; Lymphocytes; Lymphocytes T; Macrophages; MyD88 protein; NF-κB protein; Nitric oxide; Phosphorylation; Poultry; Regulators; Serine; Signal transduction; Signaling; Stat1 protein; Stat3 protein; Stimulation; Tyk2 protein; Tyrosine; α-Interferon; β-Interferon

Chicken interleukin 26 (ChIL-26), a member of the IL-10 family, is expressed in T cells and can induce expression of proinflammatory cytokines. We examined the response of signal transduction pathways to ChIL-26 stimulation in the chicken T(CU91), macrophage (HD11), and fibroblast (OU2) cell lines....