Regulation of V(D)J recombination: A dominant role for promoter positioning in gene segment accessbility

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 99; no. 19; p. 12309
• Main Authors: Sikes, Michael L, Meade, Amber, Tripathi, Rajkamal, Krangel, Michael S, Oltz, Eugene M
• Format: Journal Article
• Language: English
• Published: Washington National Academy of Sciences 17.09.2002
• Subjects: Genes; Immunology

Antigen receptor gene assembly is regulated by transcriptional promoters and enhancers, which control the accessibility of gene segments to a lymphocyte-specific V(D)J recombinase. However, it remained unclear whether accessibility depends on the process of transcription itself or chromatin modifica...