IFN-[gamma] receptor signaling mediates spinal microglia activation driving neuropathic pain

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 106; no. 19; p. 8032
• Main Authors: Tsuda, Makoto, Masuda, Takahiro, Kitano, Junko, Shimoyama, Hiroshi, Tozaki-Saitoh, Hidetoshi, Inoue, Kazuhide
• Format: Journal Article
• Language: English
• Published: Washington National Academy of Sciences 12.05.2009
• Subjects: Cells; Cytokines; Genetics; Neurons; Pain

Neuropathic pain, a highly debilitating pain condition that commonly occurs after nerve damage, is a reflection of the aberrant excitability of dorsal horn neurons. This pathologically altered neurotransmission requires a communication with spinal microglia activated by nerve injury. However, how no...