Long-Term Safety of In Utero Exposure to Anti-TNF[alpha] Drugs for the Treatment of Inflammatory Bowel Disease: Results from the Multicenter European TEDDY Study

• Published in: The American journal of gastroenterology Vol. 113; no. 3; p. 396
• Main Authors: Chaparro, M, Verreth, A, Lobaton, T, Gravito-soares, E, Julsgaard, M, Savarino, E, Magro, F, Avni Biron, I, Lopez-serrano, P, Casanova, M J, Gompertz, M, Vitor, S, Arroyo, M, Pugliese, D, Zabana, Y, Vicente, R, Aguas, M, Bar-gil Shitrit, A, Gutierrez, A, Doherty, G A, Fernandez-salazar, L, Martínez Cadilla, J, Huguet, J M, O'toole, A, Stasi, E, Manceñido Marcos, N, Villoria, A, Karmiris, K, Rahier, J F, Rodriguez, C, Diz-lois Palomares, M, Fiorino, G, Benitez, J M, Principi, M, Naftali, T, Taxonera, C, Mantzaris, G, Sebkova, L, Iade, B, Lissner, D, Ferrer Bradley, I, Lopez-san Roman, A, Marin-jimenez, I, Merino, O, Sierra, M, Van Domselaar, M, Caprioli, F, Guerra, I, Peixe, P, Piqueras, M, Rodriguez-lago, I, Ber, Y, Van Hoeve, K, Torres, P, Gravito-soares, M, Rudbeck-resdal, D, Bartolo, O, Peixoto, A, Martin, G, Armuzzi, A, Garre, A, Donday, M G, Martín De Carpi, F J, Gisbert, J P
• Format: Journal Article
• Language: English
• Published: New York Wolters Kluwer Health Medical Research, Lippincott Williams & Wilkins 01.03.2018
• Subjects: Drugs; Gastroenterology; Infections; Inflammatory bowel disease; Pregnancy; Tumor necrosis factor-TNF

Objectives:The long-term safety of exposure to anti-tumor necrosis factor (anti-TNFα) drugs during pregnancy has received little attention. We aimed to compare the relative risk of severe infections in children of mothers with inflammatory bowel disease (IBD) who were exposed to anti-TNFα drugs in u...