Integrin [alpha]^sub 4^[beta]^sub 1^ regulates migration across basement membranes by lung fibroblasts: A role for phosphatase and tensin homologue deleted on chromosome 10

• Published in: American journal of respiratory and critical care medicine Vol. 168; no. 4; p. 436
• Main Authors: White, Eric S, Thannickal, Victor J, Carskadon, Shannon L, Dickie, Emily G
• Format: Journal Article
• Language: English
• Published: New York American Thoracic Society 15.08.2003
• Subjects: Chromosomes; Cloning; Collagen; Extracellular matrix; Fibroblasts; Flow cytometry; Genotype & phenotype; Membranes; Pathophysiology; Phosphatase; Pneumonia; Pulmonary fibrosis; Thoracic surgery

Idiopathic pulmonary fibrosis is a disease that is characterized by fibroblast accumulation and activation in the distal airspaces of the lung. We hypothesized that fibrotic lung fibroblasts migrate/invade across basement membranes by integrin-mediated mechanisms as a means of entering alveoli. We d...