Activation of coagulation system during air travel/Authors' reply

A M J Schreijer and colleagues (March 11, p 832)1 exposed 71 healthy young volunteers with factor V Leiden mutation, oral contraceptive use, or both, to an 8-h flight simulation followed by an 8-h movie marathon 2 weeks later, and compared their coagulation activity to that found in routine daily li...

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Bibliographic Details
Published inThe Lancet (British edition) Vol. 368; no. 9529; p. 25
Main Authors Bertoni, Gabriele B, Rampoldi, Vincenzo, Schreijer, A J M, Cannegieter, S C
Format Journal Article
LanguageEnglish
Published London Elsevier Limited 01.07.2006
Subjects
Air transportation
Aircraft
Birth control
Coagulation
Risk factors
Studies
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Summary:A M J Schreijer and colleagues (March 11, p 832)1 exposed 71 healthy young volunteers with factor V Leiden mutation, oral contraceptive use, or both, to an 8-h flight simulation followed by an 8-h movie marathon 2 weeks later, and compared their coagulation activity to that found in routine daily life. Moreover, in the exclusion criteria, Schreijer and colleagues only vaguely refer to "disease affecting coagulation", without specifying whether efforts were made to screen for other potential risk factors-eg, methylene tetrahydrofolate reductase deficiency, antithrombin III levels, protein C and S functionality, antiphospholipid antibodies including lupus anticoagulant, and high serum homocysteine that could have affected the results.
ISSN:0140-6736
1474-547X