A mixture model-based discriminate analysis for identifying ordered transcription factor binding site pairs in gene promoters directly regulated by estrogen receptor-[alpha]

• Published in: Bioinformatics (Oxford, England) Vol. 22; no. 18; p. 2210
• Main Authors: Lang, Li, Cheng, Alfred S L, Jin, Victor X, Paik, Henry H, Fan, Meiyun, Li, Xiaoman, Zhang, Wei, Robarge, Jason, Balch, Curtis, Davuluri, Ramana V, Sun, Kim, Tim H.-M. Huang, Nephew, Kenneth P
• Format: Journal Article
• Language: English
• Published: Oxford Oxford Publishing Limited (England) 15.09.2006

Motivation: To detect and select patterns of transcription factor binding sites (TFBSs) which distinguish genes directly regulated by estrogen receptor-α (ERα), we developed an innovative mixture model-based discriminate analysis for identifying ordered TFBS pairs. Results: Biologically, our propose...