Cancer-associated fibroblasts lead tumor invasion through integrin-ß3–dependent fibronectin assembly

• Published in: The Journal of cell biology Vol. 216; no. 11; p. 3509
• Main Authors: Attieh, Youmna, Clark, Andrew G, Grass, Carina, Richon, Sophie, Pocard, Marc, Mariani, Pascale, Elkhatib, Nadia, Betz, Timo, Gurchenkov, Basile, Vignjevic, Danijela Matic
• Format: Journal Article
• Language: English
• Published: New York Rockefeller University Press 01.11.2017
• Subjects: Assembly; Cancer; Contractility; Degradation; Fibroblasts; Fibronectin; Integrins; Lead; Stiffening; Stroma; Tumors

Cancer-associated fibroblasts (CAFs) are the most abundant cells of the tumor stroma. Their capacity to contract the matrix and induce invasion of cancer cells has been well documented. However, it is not clear whether CAFs remodel the matrix by other means, such as degradation, matrix deposition, o...