Dietary Calcium and Cholecalciferol Modulate Cyclin D1 Expression, Apoptosis, and Tumorigenesis in Intestine of adenomatous polyposis coli^sup 1638N/+^ Mice1,2

• Published in: The Journal of nutrition Vol. 138; no. 9; p. 1658
• Main Authors: Yang, Kan, Lamprecht, Sergio A, Shinozaki, Hiroharu, Fan, Kunhua, Yang, WanCai, Newmark, Harold L, Kopelovich, Levy, Edelmann, Winfried, Jin, Bo, Gravaghi, Claudia, Augenlicht, Leonard, Kucherlapati, Raju, Lipkin, Martin
• Format: Journal Article
• Language: English
• Published: Bethesda American Institute of Nutrition 01.09.2008
• Subjects: Apoptosis; Cancer; Diet; Nutrition; Proteins; Rodents

Both epidemiological and experimental findings have indicated that components of Western diets influence colonic tumorigenesis. Among dietary constituents, calcium and cholecalciferol have emerged as promising chemopreventive agents. We have demonstrated that a Western-style diet (WD) with low level...