Aspergillusￂ fumigatus protein phosphatase PpzA is involved in iron assimilation, secondary metabolite production, and virulence

• Published in: Cellular microbiology Vol. 19; no. 12
• Main Authors: Manfiolli, Adriana Oliveira, Castro, Patrícia Alves, Reis, Thaila Fernanda, Dolan, Stephen, Doyle, Sean, Jones, Gary, Riano Pachon, Diego M, Ulas, Mevlut, Noble, Luke M, Mattern, Derek J, Brakhage, Axel A, Valiante, Vito, Silva-Rocha, Rafael, Bayram, Ozgur, Goldman, Gustavo H
• Format: Journal Article
• Language: English
• Published: Oxford Hindawi Limited 01.12.2017
• Subjects: Animal models; Aspergillosis; Assimilation; Biological activity; Heavy metals; Helvolic acid; Immunocompromised hosts; Infections; Iron; Liquid chromatography; Mass spectrometry; Mass spectroscopy; Metabolites; Neutropenia; Pathogenicity; Phosphatase; Protein phosphatase; Proteins; Proteomics; Starvation; Virulence

Summary Metal restriction imposed by mammalian hosts during an infection is a common mechanism of defence to reduce or avoid the pathogen infection. Metals are essential for organism survival due to its involvement in several biological processes. Aspergillus fumigatus causes invasive aspergillosis,...