Subchronic 17[alpha]-ethinyl estradiol differentially affects subtypes of sleep and wakefulness in ovariectomized rats

• Published in: Hormones and behavior Vol. 53; no. 1; p. 217
• Main Authors: Pawlyk, Aaron C, Alfinito, Peter D, Johnston, Grace H, Deecher, Darlene C
• Format: Journal Article
• Language: English
• Published: New York Elsevier BV 01.01.2008
• Subjects: Circadian rhythm; Estrogens; Females; Rodents; Sleep

In ovariectomized (OVX) Sprague-Dawley rats, estradiol benzoate (EB) has been reported to decrease rapid eye movement (REM) and non-REM (NREM) sleep during the dark phase for up to 3 days. It is unknown, however, if estrogenic effects on sleep extend beyond 3 days or if other estrogens could induce...