A distinct subpopulation of CD25^sup -^ T-follicular regulatory cells localizes in the germinal centers

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 114; no. 31; p. E6400
• Main Authors: Wing, James Badger, Kitagawa, Yohko, Locci, Michela, Hume, Hannah, Tay, Christopher, Morita, Takayoshi, Kidani, Yujiro, Matsuda, Kyoko, Inoue, Takeshi, Kurosaki, Tomohiro, Crotty, Shane, Coban, Cevayir, Ohkura, Naganari, Sakaguchi, Shimon
• Format: Journal Article
• Language: English
• Published: Washington National Academy of Sciences 01.08.2017
• Subjects: CD25 antigen; Cell differentiation; Cell survival; Cells; CXCR5 protein; Differentiation (biology); Effector cells; Foxp3 protein; Genes; Germinal centers; Immunoregulation; Interleukin 2; Lymphocytes B; Lymphocytes T; Molecules; PD-1 protein

T-follicular helper (Tfh) cells differentiate through a multistep process, culminating in germinal center (GC) localized GC-Tfh cells that provide support to GC-B cells. T-follicular regulatory (Tfr) cells have critical roles in the control of Tfh cells and GC formation. Although Tfh-cell differenti...