The innate immune receptor MDA5 limits rotavirus infection but promotes cell death and pancreaticￂ inflammation

• Published in: The EMBO journal Vol. 36; no. 18; p. 2742
• Main Authors: Dou, Yu, Yim, Howard CH, Kirkwood, Carl D, Williams, Bryan RG, Sadler, Anthony J
• Format: Journal Article
• Language: English
• Published: Heidelberg Blackwell Publishing Ltd 01.09.2017
• Subjects: Alleles; Apoptosis; Autoimmunity; Beta cells; Cell death; Cytokines; Damage; Diabetes; Diabetes mellitus; Differentiation; Etiology; Functional analysis; Immune response; Immune system; Infections; Inflammation; Innate immunity; Interferon; Melanoma; Mortality; Pancreas; Risk; Rotavirus; Viruses

Melanoma differentiation-associated protein 5 (MDA5) mediates the innate immune response to viral infection. Polymorphisms in IFIH1, the gene coding for MDA5, correlate with the risk of developing type 1 diabetes (T1D). Here, we demonstrate that MDA5 is crucial for the immune response to enteric rot...