Paeoniflorin Suppressed High Glucose-Induced Retinal Microglia MMP-9 Expression and Inflammatory Response via Inhibition of TLR4/NF-[kappa]B Pathway Through Upregulation of SOCS3 in Diabetic Retinopathy

• Published in: Inflammation Vol. 40; no. 5; p. 1475
• Main Authors: Zhu, Su-hua, Liu, Bing-qian, Hao, Mao-juan, Fan, Yi-xin, Qian, Cheng, Teng, Peng, Zhou, Xiao-wei, Hu, Liang, Liu, Wen-tao, Yuan, Zhi-lan, Li, Qing-ping
• Format: Journal Article
• Language: English
• Published: New York Springer Nature B.V 01.10.2017
• Subjects: Diabetes; Diabetes mellitus; Diabetic retinopathy; Gelatin; Gelatinase B; Glucose; HMGB1 protein; Hyperglycemia; Immunofluorescence; Immunomodulation; Inflammation; Interleukin 1; MAP kinase; Matrix metalloproteinase; Metalloproteinase; Microglia; NF-κB protein; Phosphorylation; Retina; Retinopathy; Rodents; Signal transduction; SOCS-3 protein; Streptozocin; TLR4 protein; Toll-like receptors; Up-regulation

Diabetic retinopathy (DR) is a serious-threatening complication of diabetes and urgently needed to be treated. Evidence has accumulated indicating that microglia inflammation within the retina plays a critical role in DR. Microglial matrix metalloproteinase 9 (MMP-9) has an important role in the des...