Synergistic targeting of breast cancer stem-like cells by human [gamma][delta] T cells and CD8+ T cells

• Published in: Immunology and cell biology Vol. 95; no. 7; p. 620
• Main Authors: Chen, Hung-chang, Joalland, Noémie, Bridgeman, John S, Alchami, Fouad S, Jarry, Ulrich, Khan, Mohd Wajid A, Piggott, Luke, Shanneik, Yasmin, Li, Jianqiang, Herold, Marco J, Herrmann, Thomas, Price, David A, Gallimore, Awen M, Clarkson, Richard W, Scotet, Emmanuel, Moser, Bernhard, Eberl, Matthias
• Format: Journal Article
• Language: English
• Published: London Blackwell Science Ltd 01.08.2017
• Subjects: Antigens; Breast cancer; Cancer; CD8 antigen; Cell culture; Cell self-renewal; Farnesyl pyrophosphate synthase; Immunotherapy; Intercellular adhesion molecule 1; Lymphocytes; Lymphocytes T; Major histocompatibility complex; Malignancy; Mesenchyme; Monoclonal antibodies; Phenotypes; Ribonucleic acid; RNA; Stem cell transplantation; Stem cells; Tumorigenicity; Tumors; Xenografts; Zoledronic acid

The inherent resistance of cancer stem cells (CSCs) to existing therapies has largely hampered the development of effective treatments for advanced malignancy. To help develop novel immunotherapy approaches that efficiently target CSCs, an experimental model allowing reliable distinction of CSCs and...